Applications

What a native-state structure makes possible.

Your target resolved in its real lipid environment, applied to the decisions where membrane-protein programs usually stall.

01Solve a target that won't survive detergents.Get a high-resolution structure of your membrane protein in its native lipid environment, not a detergent artifact.

What You Get

Sub-3Å single-particle cryo-EM in a native membrane bilayer
Static and dynamic structures built with the proprietary NCMN System
A full structural report with PDB-ready coordinates

02Tell real binding pockets from lipid-filled ones.Map where native lipids actually sit, so you don't screen against pockets that aren't truly open.

What You Get

Identification of true native lipid interactions
Flags on sites that detergent structures mistake for drug pockets
Input that sharpens virtual-screening triage

03Capture the state your drug needs to target.Resolve your target across the functional states that matter for allosteric and structure-based design.

What You Get

Structures in multiple states, static and dynamic (apo, ligand-bound, G-protein-coupled, inhibitor-bound)
All in a physiologically relevant membrane context
A basis for allosteric drug discovery

04Confirm the structure is the working protein.Validate that what you are designing against behaves like the real, functional target.

What You Get

Biochemical activity assays
Confirmation that NCMN particles retain full functionality
Structures validated against native function, not just homogeneity

05Built for AI-powered drug discovery.The NCMN System produces structures ready for computational chemistry and AI-enabled design workflows.

What You Get

Coordinates processed for docking, MD simulation, and pharmacophore modeling
Lipid occupancy clearly annotated to reduce false-positive screening hits
Structures compatible with third-party AI drug-discovery platforms such as AIDDISON™ and SYNTHIA®

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What a native-state structure makes possible.

Better outcomes start with the right structure.